Chromosome-12 Mapping of Late-Onset Alzheimer Disease among Caribbean Hispanics
نویسندگان
چکیده
منابع مشابه
Genetic studies on chromosome 12 in late-onset Alzheimer disease.
CONTEXT The only genetic locus universally accepted to be important as a risk factor for late-onset Alzheimer disease (AD) is the apolipoprotein E (APOE) locus on chromosome 19. However, this locus does not account for all the risk in late-onset disease, and a recent report has suggested a second locus on chromosome 12p11-12. OBJECTIVE To look for evidence of linkage on chromosome 12 and to t...
متن کاملGenome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.
Only Apolipoprotein E polymorphisms have been consistently associated with the risk of late-onset Alzheimer disease (LOAD), but they represent only a minority of the underlying genetic effect. To identify additional LOAD risk loci, we performed a genome-wide association study (GWAS) on 492 LOAD cases and 498 cognitive controls using Illumina's HumanHap550 beadchip. An additional 238 cases and 2...
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OBJECTIVES To reexamine the association between the apolipoprotein E epsilon4 allele (APOE epsilon4) and familial Alzheimer disease (AD), and to search for novel genes that may be associated with susceptibility in Caribbean Hispanic families with a history of AD. METHODS Families were identified in Caribbean Hispanic communities in the greater New York City area, the Dominican Republic, and P...
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OBJECTIVES To identify novel candidate regions for late-onset Alzheimer disease (LOAD) and to confirm linkage in previously identified chromosomal regions. DESIGN Family-based linkage analysis. SETTING Probands with familial LOAD identified in clinics in the Dominican Republic, Puerto Rico, and the United States. Patients We conducted a genome scan in 1161 members primarily clinically diagn...
متن کاملPathophysiology of Late Onset Alzheimer Disease
As the world population has aged, the number of people affected by Alzheimer Disease is rapidly increasing in the world. It is important for clinicians to recognize early signs and symptoms of dementia and to note potentially modifiable risk factors and early disease markers. Accumulation of A┚ peptides may be the key event in pathogenesis of AD. The exact mechanism by which A┚ peptide depositi...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2002
ISSN: 0002-9297
DOI: 10.1086/324773